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We arehappy to highlight some of the clinical trials that have been held with lowdoses of NTX (LDN).  With LDN being ageneric drug, it does not have the financial support of other pharmaceuticaldrugs and therefore the clinical trials to-date have been small.  That being said, all clinical trials to-datesupport the need for larger scale trials.Please see the attached link for moreinformation. We will continue to update this page as more trials get published.


Safety and Tolerability of Low-dose Naltrexone Therapy in Children With Moderate to Severe Crohn's Disease: A Pilot Study (2013)

Therapy with the opioid antagonist naltrexone promotes mucosal healing in active Crohn's disease: a randomized placebo-controlled trial (2011)

Low dose Naltrexone in the treatment of IBS (2006)


Neurologist, Dr Turel from Penn State talking about LDN and his patients with MS.

Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis (2010).

The effect of low-dose naltrexone on quality of life of patients with multiple sclerosis: a randomized placebo-controlled trial (2010).


Dr Mackay MD, PhD (Stanford) talking about Fibromyalgia (fast forward to 45mins 42 seconds)

“The preliminary evidence continues to show that low-dose naltrexone has a specific and clinically beneficial impact on fibromyalgia pain. Our clinical studies showed 1/3 response rate showing significant improvement in pain, fatigue and sleep.  When we used only the criteria of significant reduction of pain 65% are responders with 50% of the patients feeling much improved after their LDN treatment. LDN is widely available, inexpensive, safe, and well-tolerated.”

Dr. David A. McLain, MD, FACP, FACR, McLain Medical Associates, Birmingham, AL

Low-dose naltrexone for the treatment of fibromyalgia: Findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels(2013)

Low-Dose Naltrexone Decreases Anxiety, Pain, in Patients with Fibromyalgia (2013)

Low Dose Naltrexone In The Treatment Of Fibromyalgia (2013)

Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study (2009)


Single cohort study of the effect of low dose naltrexone on the evolution of immunological, virological and clinical state of HIV+ adults in Mali (2011)

Impact of low dose naltrexone (LDN) on antiretroviral therapy (ART) treated HIV+ adults in Mali: A single blind randomized clinical trial (2011)


Low dose naltrexone in the treatment of dissociative symptoms (Nov 2014)


Phase 2 Study Showing Promise for Patients with Charcot-Tooth-Marie